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Therapeutic Area

Rheumatoid Arthritis
(Reference No: M542)

Eligibility Criteria

Males or females aged 18+ years and who have been diagnosed with rheumatoid arthritis and who have had an inadequate response to biologic disease-modifying antirheumatic drugs (bDMARDs).

Trial Details

Approx. 11 clinic visits over 7 months.

Status

Active, no longer recruiting

Therapeutic Area

Rheumatoid Arthritis (Reference No: M545)

Eligibility Criteria

Males or females aged 18+ years and who have been diagnosed with rheumatoid arthritis and who have had <3 doses of methotrexate.

Trial Details

Approx. 16 clinic visits over 6 months.

Status

Active, no longer recruiting

Therapeutic Area

Rheumatoid Arthritis (Reference No: M549)

Eligibility Criteria

Males or females aged 18+ years and who have been diagnosed with rheumatoid arthritis and who have had an inadequate response to conventional synthetic disease-modifying antirheumatic drugs (csDMARDs).

Trial Details

Approx. 8 clinic visits over 4 months.

Status

Active, no longer recruiting

Therapeutic Area

Rheumatoid Arthritis (Reference No: M565)

Eligibility Criteria

Males or females aged 18+ years and who have been diagnosed with rheumatoid arthritis and who have had an inadequate response to methotrexate.

Trial Details

Approx. 14 clinic visits + 2 telephone contacts over 15 months.

Status

In progress

Therapeutic Area

Psoriatic Arthritis
(Reference No: 2366)

Eligibility Criteria

Males and Females aged 18+ years and who have been diagnosed with psoriatic arthritis and have had inadequate treatment responses to nonsteroidal anti-inflammatory drugs (NSAIDs) and classic disease-modifying antirheumatic drugs (cDMARDs) including methotrexate.

Trial Details

Approx. 33 clinic visits over 16 months.

 

Status

In progress

Therapeutic Area

Ankylosing Spondylitis

Eligibility Criteria

  • Male or female adults 18+ years old
  • Radiographic criteria documented by the central reader
  • Clinical criteria documented in physical examination

Trial Details

5 years
Visits at weeks 4, 12, 16, 24, then quarterly

Status

In progress

Therapeutic Area

Psoriatic Arthritis

Eligibility Criteria

  • Male or female adults 18+ years old
  • Willing and able to undergo MRI scans
  • Stable dose of PsA treatment

Trial Details

1 year
Quarterly visits

Status

In progress

Therapeutic Area

Rheumatoid Arthritis

Eligibility Criteria

  • Male or female adults 18+ years old
  • Completion of a qualifying parent study

Trial Details

4 year extension study with quarterly visits

Status

In progress

Therapeutic Area

Psoriatic Arthritis

Eligibility Criteria

  • Male or female adults 18+ years old
  • Have been treated with 1+ cDMARDs
  • Have had prior treatment with at least 1 and not more than 2 TNF inhibitors

Trial Details

3 years
Year 1: weeks 1, 2, 4, 8, 12, 16, 20, 24, 28, 32, 36, 44, 52
Year 2-3:
Quarterly visits

Status

In progress

Therapeutic Area

Psoriatic Arthritis Who Are Biologic Disease-Modifying Anti-Rheumatic Drug Naive

Eligibility Criteria

  • Male or female adults 18+ years old
  • Cannot have used csDMARDs other than MTX, leflunomide, sulfasalazine, or cyclosporine or hydroxychloroquine in the 8 weeks prior to randomization
  • Have received any prior, or are currently receiving, treatment with any bDMARD therapy or small-molecule for PsA or for psoriasis

Trial Details

1 year

Status

Coming soon

Therapeutic Area

Type 2 Diabetes

Eligibility Criteria

  • Male or female adults 18-70yo
  • Body Mass Index (BMI) ≥27 kg/m2 and <40 kg/m2
  • Must meet laboratory criteria for HbA1C, C-peptide and lipids
  • Able to maintain a paper diary

Trial Details

Up to 21 weeks

Status

Coming soon

Therapeutic Area

Chronic Obstructive Pulmonary Disease

Eligibility Criteria

  • Males and females 40+ years
  • Outpatient with a diagnosis of COPD
  • FEV1 and CAT score criteria
  • Completion of an electronic diary

Trial Details

Six months

Status

Coming soon

Therapeutic Area

Systemic Lupus Erythematosus

Eligibility Criteria

  • Males and females 18-75 years of age
  • Have SLE by meeting the SLICC classification criteria
  • ANA, and/or anti-dsDNA antibodies, and/or anti-Smith antibodies eligibility criteria
  • BILAG and SLEDAI-2K eligibility criteria

Trial Details

2 years
Monthly visits

Status

In progress

Therapeutic Area

Psoriatic Arthritis

Eligibility Criteria

  • Male or female adults 18+ years old
  • Diagnosis of PsA classified by CASPAR criteria
  • Rheumatoid factor (RF) and anti-cyclic citrullinated peptide (anti-CCP) antibodies negative at screening
  • Prior or current NSAID use
  • Cannot have used biologics except those targeting TNF (but no more than 3 agents used)

Trial Details

2 years
Year 1: Weekly visits for 4 weeks, then monthly
Year 2: Quarterly visits

Status

In progress

Therapeutic Area

Psoriatic Arthritis

Eligibility Criteria

  • This is an extension study from a 2 year parent study

Trial Details

3 years
Quarterly visits

Status

In progress

Therapeutic Area

Psoriatic Arthritis

Eligibility Criteria

  • Male or female adults 18+ years old
  • Diagnosis of PsA classified by CASPAR criteria
  • Rheumatoid factor (RF) and anti-cyclic citrullinated peptide (anti-CCP) antibodies negative at screening
  • Prior or current NSAID use

Trial Details

3 years
Year 1: Weekly visits for 4 weeks, then monthly
Year 2: Every 2 months
Year 3:  Quarterly visits

Status

In progress

Therapeutic Area

Psoriatic Arthritis

Eligibility Criteria

  • Male or female adults 18+ years old
  • Diagnosis of PsA classified by CASPAR criteria
  • Rheumatoid factor (RF) and anti-cyclic citrullinated peptide (anti-CCP) antibodies negative at screening
  • Prior or current NSAID use

Trial Details

5 years
Year 1-2: Weekly visits for 4 weeks, then monthly
Year 3-5: Quarterly visits

Status

In progress

Therapeutic Area

Ankylosing spondylitis

Eligibility Criteria

  • Male or female adults 18+ years old
  • Diagnosis of moderate to severe AS with prior documented radiologic evidence
  • BASDAI eligibility
  • NSAID use with an inadequate response or failure to respond

Trial Details

2 years
Year 1: Weekly visits for 4 weeks, then monthly
Year 2: Quarterly visits

Status

In progress

Therapeutic Area

Rheumatoid arthritis

Eligibility Criteria

  • Male or female adults 18+ years old
  • Have moderate to severe disease activity as defined by CDAI>10and DAS28-4(ESR) ≥3.2at Baseline Visit
  • Joint count eligibility
  • Methotrexate 4+ months with an inadequate response
  • Cannot have had a history of insufficient response to ≥2 biologics, regardless of the class

Trial Details

48 weeks
Visits: weeks 6, 12, 24, 36, 48

Status

Coming soon

Therapeutic Area

Psoriatic Arthritis
(Reference No: 2366)

Eligibility Criteria

  • This is a long-term extension study from a qualifying parent study

Trial Details

3 years
Visits: Quarterly

Status

In progress

Therapeutic Area

Axial spondyloarthritis

Eligibility Criteria

  • Male or female adults 18+ years old
  • Meets ASAS criteria
  • Subjects must NOT have sacroiliitis defined by mNY criteria on SI x-rays
  • BASDAI eligibility criteria
  • MRI+/CRP+ or MRI+/CRP- or MRI-/CRP+
  • Prior use of 2+ NSAIDs

Trial Details

1 Year
Monthly visits

Status

In progress

Therapeutic Area

Knee Pain due to Osteoarthritis

Eligibility Criteria

  • Males and females 40-70yo
  • Knee pain for 12+ months
  • Radiographic evidence of osteoarthritis by Kellgren-Lawrence classification Grade 2, 3, or 4
  • Able and willing to maintain a daily pain and daily skin check diary

Trial Details

12 weeks
Visits: Monthly

Status

In progress

Therapeutic Area

Healthy volunteers for a vaccine

Eligibility Criteria

  • Aged 50+
  • Subjects with an increased risk of future contact with healthcare systems (e.g. had hospitalisation/emergency room visit in the last 12 months), or recent antibiotic use

Trial Details

Endpoint driven

Status

Coming soon